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APPLICATIONS

• Enantiomeric purity on scale up.
• HKR reactions do not require solvent thus leading to excellent volumetric productivity and low costs.
• HKR catalyst stable and can survive extended heating at elevated temperatures with no ill effects.
• Re-use of HKR catalyst with the same yield and selectivity.

Buchwald group from Massachusetts Institute of Technology has developed an efficient and safe procedure for the large scale organometallic-catalysed coupling reactions (C-C, C-N, C-O, C-S) of aromatic halides or pseudo-halides. Shasun has an exclusive world-wide license to this technology which is utilized for the ability of C-C, C-N and C-O bond formations.

S-Phos

1. Ligands used in the palladium catalyzed Suzuki-Miyaura coupling of aryl and alkyl boronic acids and esters with aryl and heteroaryl halides.
2. Suzuki-Miyaura cross-coupling of potassium aryl trifluoroborates with aryl chlorides.
3. Used with Au(I) for intramolecular cycloaddition of 1,3-enzymes and arylalkynes with alkenes.
4. Used for the Pd-catalysed amination of heteroaryl halides.

Me-Phos

1. Ligand for the Pd-catalyzed formation of alpha-arylketones and amination reaction.

X-Phos

1. Exceptional ligand for the Pd-catalysed amination of aryl halides and sulfonates.
2. Air Stable and easily handled.
3. Palladium-catalyzed amination of aryl sulfonates.

JohnPhos

1. Ligand employed in an extremely general method for the Pd-catalysed synthesis of aromatic amines using aryl chlorides, bromides and triflates.
2. Ligand employed in a very active and general catalyst for Suzuki coupling reactions using aryl chlorides, bromides and triflates.
3. Ligand for the Pd-catalyzed formation of diarylethers for aryl chlorides or bromides.
4. Ligand used in palladium-catalyzed synthesis of oxindoles from alpha-chloroacetanilides.
5. Effective ligand used in palladium-catalyzed arylation of thiazoles.
6. Used in the formation of 2-benzylindolines via sequential Pd-catalyzed N-arylation/cyclization/C-arylation.
7. Selective in the Pd-catalyzed arylation of silyl enol ethers formed from Cu-catalyzed reduction of enones.

DavePhos

1. Ligand used in the palladium-catalyzed Suzuki coupling and amination of unactivated aryl chloride. The reactions generally occur at room temperature and give high yields of product.
2. Ligand used in palladium-catalyzed C-N bond formation. A general synthesis if N6-aryl-2’-deoxyadenosine analogues.
3. Ligand used in palladium-catalyzed N-arylation of indoles.
4. Ligand used in palladium-catalyst synthesis of aryl-tert-butyl ethers.
5. Effective ligand in the palladium-catalyzed arylation of ester enolates.
6. Ligand employed in arylation of ketone enolates using ortho-halo nitrobenzenes.
7. Ligand employed in the amination of aryl nonaflates using palladium catalysts.
8. Ligand used for the cascade alkenyl amination/Heck reaction for the synthesis of indoles.
9. Used for the Pd-catalyzed amination of heteroaryl halides.